Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) at Concept Fertility Clinic
What is PGT-M?
Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) is a specialized technique used during IVF to identify specific genetic conditions in embryos. This advanced screening helps couples who are at risk of passing on a hereditary genetic disorder to ensure that only embryos free from the condition are selected for transfer.
PGT-M is a powerful tool that provides families with peace of mind and significantly reduces the risk of transmitting certain genetic conditions to their children.
How Does PGT-M Work?
PGT-M involves the following steps:
- Genetic Analysis of Parents: Before IVF begins, we analyze the DNA of both parents (or egg/sperm donors, if applicable) to identify the specific gene mutation or condition to be tested.
- IVF Treatment: Eggs are retrieved and fertilized in our laboratory to create embryos.
- Embryo Biopsy: On day 5 or 6, when embryos reach the blastocyst stage, a few cells are carefully removed from the embryo’s outer layer. This does not harm the embryo.
- Genetic Testing: The biopsied cells are tested in for the targeted condition.
- Embryo Selection: Embryos free from the genetic condition are selected for transfer, giving the highest chance of a healthy pregnancy.
Who Should Consider PGT-M?
PGT-M is recommended for individuals or couples who:
- Have a family history of a specific genetic condition.
- Are carriers of a genetic disorder (e.g., cystic fibrosis, Tay-Sachs disease, sickle cell anemia, etc).
- Have had previous children affected by a genetic condition.
- Want to minimize the risk of passing on an inherited disorder to their child.
Conditions Commonly Screened with PGT-M
PGT-M can be used to test for a wide range of genetic conditions, including:
- Cystic fibrosis
- Huntington’s disease
- Sickle cell anemia
- Tay-Sachs disease
- BRCA1 and BRCA2 gene mutations
- Duchenne muscular dystrophy
If you have a specific condition in mind, our team can advise whether PGT-M is suitable for your case.
Benefits of PGT-M
- Prevention of Genetic Disorders: Significantly reduces the risk of passing on hereditary conditions.
- Informed Family Planning: Provides clarity and control in building your family.
- Improved Confidence: Helps you move forward with your fertility journey knowing you are taking steps to protect your future child’s health.
Is PGT-M Safe?
Yes, PGT-M is a safe and well-established procedure. The embryo biopsy is performed by our experienced embryologists using advanced techniques to ensure the safety and integrity of the embryo. Embryos undergoing testing can also be frozen and stored for future use.
What Are the Limitations of PGT-M?
While PGT-M is highly effective, it is important to understand:
- It only tests for specific genetic conditions identified beforehand.
- It does not guarantee a pregnancy or rule out all potential medical conditions.
- The testing process may take extra time for the genetic analysis and preparation.
Why Choose Concept Fertility for PGT-M?
At Concept Fertility Clinic, we pride ourselves on offering cutting-edge genetic testing services alongside compassionate care. Our highly skilled team of specialists works closely with you to design a personalized treatment plan tailored to your unique needs. Our in clinic laboratory uses state-of-the-art equipment to ensure precise testing and optimal outcomes.
We understand the emotional and physical challenges of fertility treatment and are here to guide and support you every step of the way.
How to Get Started with PGT-M
If you’re considering PGT-M, the first step is a consultation with one of our fertility specialists/embryologists. We’ll discuss your medical history, family background, and how PGT-M can fit into your IVF treatment plan.
