Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR) at Concept Fertility Clinic
What is PGT-SR?
Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR) is an advanced genetic screening used during IVF to identify embryos with chromosomal structural abnormalities. These abnormalities, such as translocations, inversions, or deletions, can make it difficult to achieve a successful pregnancy or result in recurrent miscarriages.
PGT-SR is designed for individuals or couples who carry chromosomal rearrangements and want to ensure that only embryos with the correct chromosome structure are selected for transfer.
How Does PGT-SR Work?
PGT-SR can be part of an IVF cycle and involves several steps:
- Parental Chromosome Analysis: Before starting IVF, we analyze the chromosomes of both parents (or egg/sperm donors) to identify the specific structural rearrangement causing concerns.
- IVF Process: Eggs are collected and fertilized in the laboratory to create embryos.
- Embryo Biopsy: At the blastocyst stage (day 5 or 6 of development), a few cells are gently removed from the embryo for testing. This process does not harm the embryo.
- Genetic Testing: The biopsied cells are checked for the specific chromosomal rearrangement.
- Embryo Selection: Only embryos with the correct chromosome structure are selected for transfer, increasing the likelihood of a healthy pregnancy.
Who Should Consider PGT-SR?
PGT-SR may be recommended for:
- Individuals or couples known to carry chromosomal structural rearrangements, such as translocations or inversions.
- Couples with a history of recurrent miscarriages.
- Those who have experienced repeated IVF failures.
- Couples with a family history of chromosomal abnormalities.
What Types of Structural Rearrangements Can Be Tested?
PGT-SR can identify various chromosomal structural abnormalities, including:
- Balanced Translocations: Where segments of chromosomes are rearranged but no genetic material is lost or gained.
- Unbalanced Translocations: Where there is extra or missing genetic material, often causing health or developmental issues.
- Inversions: Where a segment of a chromosome is reversed.
- Deletions or Duplications: Where parts of a chromosome are missing or duplicated.
Benefits of PGT-SR
- Reduced Risk of Miscarriage: By selecting embryos with the correct chromosome structure, the risk of pregnancy loss is significantly reduced.
- Improved Pregnancy Outcomes: PGT-SR increases the chances of a successful and healthy pregnancy.
- Tailored Family Planning: Helps couples with known chromosomal issues make informed decisions about their family-building options.
Is PGT-SR Safe?
Yes, PGT-SR is a safe procedure. The embryo biopsy is performed by highly trained embryologists using advanced techniques to ensure the embryo’s health is not compromised. Biopsied embryos can be frozen while waiting for testing results and preserved for future use.
What Are the Limitations of PGT-SR?
While PGT-SR provides valuable insights, it is important to note:
- It only tests for structural rearrangements and does not identify other genetic or health conditions.
- It does not guarantee a successful pregnancy.
- Additional time may be required to complete the genetic testing.
Why Choose Concept Fertility for PGT-SR?
At Concept Fertility, we offer cutting-edge genetic testing services like PGT-SR in our clinic, in a supportive and compassionate environment. Our advanced laboratory and experienced genetic specialists ensure accurate testing and optimal outcomes.
We tailor our care to meet your unique needs, helping you navigate your fertility journey with confidence. Our team is here to guide and support you every step of the way, ensuring you receive the best possible care.
How to Get Started with PGT-SR
The first step is a consultation with one of our fertility specialists/embryologists. We’ll review your medical history, discuss your chromosomal concerns, and determine whether PGT-SR is the right choice for your IVF treatment plan.
